Endocrine Abstracts

Introduction: Teriparatide is prescribed for severe osteoporosis based on national protocols. The osteoanabolic drug is followed by an anti-resorbtive medication.Aim: We analyze the treatment sequence options after Teriparatide in patients who finished the 2-year protocol or were early droppers.Material and method: This is a real life study based on Romanian protocol of Teriparatide for severe primary or/and glucocorticoid osteopor...

Background: Prolactinomas are the most common hormone-secreting pituitary tumors and are a common cause of anovulation and infertility. Giant prolactinomas (0.5–4.4% of all pituitary tumors) are rare tumors characterized by their large size (>4 cm), compressive symptoms and extremely high prolactin secretion (>1000 ng/ml). Men are most commonly affected, with a reported male to female ratio of 9:1.Case report: We present the rare case of 53-...

Introduction: Premature ovarian failure (POF) may be a part of autoimmune polyglandular syndromes that involves multiple endocrine and systemic conditions due to autoimmunity.Material and methods: We aim to present the case of a young women diagnosed with POF and Schmidt syndrome. The patient was followed in different tertiary centers of endocrinology. The informed consent was obtained.Case report: A 31-year old patient with no pri...

Introduction: Menopausal adrenal tumours may be elements of a complex panel of co-morbidities. Some of these are represented by the presence of a second pathology requiring surgery at the kidney level.Aim: We aim to introduce a series of two cases involving menopausal women who were referred for specific endocrine assays after they had a unilateral nephrectomy (UN).Method: This is a cases series observational study. The patients ga...

Introduction: Even if breast cancer is rare cause of pituitary metastases, the diagnosis of a pituitary adenoma, shortly after surgery for breast cancer, raises suspicion of a possible secondary determinations.Material and method: This is a case report revealing the medical history and endocrine profile of a female with breast cancer and pituitary macroadenoma.Case data: A 64-year old non-smoking female (with menopause at age of 52...

Introduction: Cushing’s disease (CD) is caused by high adrenocorticotropic hormone (ACTH), usually by a pituitary microadenoma.Material and method: This is a case report investigated in several Romanian centers by performing: morning plasma cortisol, circadian rhythm of plasma cortisol, plasma ACTH, dexamethasone (DXM) suppression tests.Case data: A 57-year female, known with hypertension and osteopenia, was ...

Introduction: Cushing’s disease (CD) in youth represents a challenge especially related to the therapy and long-term management.Materials and methods: We report the medical history of a child with CD who was followed-up for 7 years. Suggestive endocrine panel and imagery is exposed.Case presentation: A 19-year female was diagnosed at age of 12 with CD. Clinical assessment revealed: weight gain, headache, hyperpigmentation pred...

Introduction: In cases with high-risk metabolic profile the investigations may lead to the discovery of an adrenal tumor (AT). Complex endocrine investigations including computed tomography (CT) scans may point anomalies of the vessels as coronary artery or abdominal aorta.Aim: We report a case associating an AT and severe cardiovascular anomalies which are discovered during endocrine investigations.Case data: A 72-year prior smoke...

Introduction: Cystic lesions of the adrenals are rare and they may develop asymptomatically for a long period of time. Females seem to be more affected and lesion is typically unilateral.Aim: We report a case of young female case incidentally found with a large adrenal pure cystic mass.Case data: A 24-year non-smoking female patient with regular menses since the age of 14 complained of mild abdominal pain for a few days without cor...

Introduction: Cushing’s syndrome (CS) is correlated with prolonged exposure to high levels of glucocorticoid hormones. Although the most common cause is exogenous adrenal tumors incidentally discovered (incidentaloma) may underline CS.Material and method: This is a case presentation of an adult patient. Specific tests for CS have been used: morning plasma cortisol and circadian rhythm, plasma ACTH, testosterone, dexamethasone (DXM) suppression test....